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ONZETRA® Xsail® (sumatriptan nasal powder) logo
Migraine Relief in as little as 30 Minutes*

Fast & Effective Migraine Relief

*A large proportion of migraine sufferers had significant pain relief  with ONZETRA (42%) vs placebo (27%)

About ONZETRA
About ONZETRA

Blow Migraine Pain Away With ONZETRA Xsail: Breath Powered® Delivery*

The unique device delivers sumatriptan in the form of a powder directly to the back of the nose.

Sumatriptan, the active ingredient in ONZETRA, is the most widely prescribed migraine medication and has been used to treat acute migraines for nearly 30 years. 

*Twice as many people taking ONZETRA were pain-free at 2 hours compared to people taking a placebo (34% vs 17% respectively).

Why it Works

The back of your nose is full of absorbent tissue and blood vessels, which allows the powder medication to be absorbed quickly.

Breath Powered delivery also limits medication from dripping into your throat or reaching your stomach or lungs.

Learn How It Works
Onzetra Xsail application device for fast relief

Blow Migraine Pain Away With ONZETRA Xsail: Breath Powered® Delivery

The unique device delivers sumatriptan in the form of a powder directly to the back of the nose.

Sumatriptan, the active ingredient in ONZETRA, is the most widely prescribed migraine medication and has been used to treat acute migraines for nearly 30 years.

*Twice as many people taking ONZETRA were pain-free at 2 hours compared to people taking a placebo (34% vs 17% respectively).

Onzetra Xsail application device for fast relief
Why it Works 

The back of your nose is full of absorbent tissue and blood vessels, which allows the powder medication to be absorbed quickly.

Breath Powered delivery also limits medication from dripping into your throat or reaching your stomach or lungs.

Learn How It Works

Do You Have Questions?

We have answers to help you better understand how ONZETRA provides relief from migraine pain.

Visit FAQs

Get Started with a Doctor

Ready to take control of your acute migraine pain? Make an appointment with a doctor online to learn if prescription ONZETRA is right for you. 

Talk to a Doctor Online about ONZETRA

Get Started with a Doctor

Ready to take control of your acute migraine pain? Make an appointment with a doctor online to learn if prescription ONZETRA is right for you. 

Talk to a Doctor Online about ONZETRA
IMPORTANT SAFETY INFORMATION
What is ONZETRA® Xsail®
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IMPORTANT SAFETY INFORMATION
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ONZETRA Xsail may cause serious side effects, including:

  • Heart attack and other heart problems, which may lead to death. Stop using ONZETRA Xsail and get emergency medical help right away if you have any symptoms of a heart attack like shortness of breath or tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw that is severe or does not go away
  • Changes in color or sensation in your fingers and toes (Raynaud’s syndrome)
  • Stomach and intestinal problems (gastrointestinal and colonic ischemic events)
  • Problems with blood circulation to your legs and feet (peripheral vascular ischemia)
  • Serious allergic reactions (symptoms include hives; tongue, mouth, lip, or throat swelling; problems breathing)
  • Medication overuse headaches. Some people who use ONZETRA Xsail too many times may have worse headaches. If your headaches get worse your doctor may decide to stop your treatment with ONZETRA Xsail
  • Serotonin syndrome, a rare but serious problem that can happen in people using ONZETRA Xsail, especially if ONZETRA Xsail is used with antidepressant medicines called SSRIs, SNRIs, or TCAs. Call your doctor right away if you have any of the following symptoms of serotonin syndrome: mental changes such as seeing things that are not there (hallucinations), agitation, or coma; fast heartbeat; changes in blood pressure; high body temperature; tight muscles; trouble walking; or nausea, vomiting, or diarrhea
  • Seizures. Seizures have happened in people taking sumatriptan who have never had seizures before

The most common side effects of ONZETRA Xsail are abnormal taste, discomfort of your nose or throat, runny nose, and stuffy nose. This is not a complete list of side effects. Tell your doctor about any side effect that bothers you or does not go away.

Who should not take ONZETRA Xsail?

Do not take ONZETRA Xsail or stop using ONZETRA Xsail if you:

  • Have heart problems or a history of heart problems
  • Have had a stroke, transient ischemic attacks (TIAs), or problems with your blood circulation
  • Have uncontrolled high blood pressure
  • Have hemiplegic migraines or basilar migraines. If you are not sure if you have these, ask your doctor
  • Have peripheral vascular disease (narrowing of blood vessels to the legs, arms, stomach, intestines, or kidneys)
  • Have taken other migraine medications in the last 24 hours, including other triptans, ergots, or ergot-type medications. Ask your doctor for a list of these medicines if you are not sure
  • Are taking a medicine called a monoamine oxidase inhibitor (MAOI). MAOIs cannot be taken within 14 days before or after taking ONZETRA Xsail
  • Have severe liver problems
  • Have an allergy to sumatriptan, the medicine in ONZETRA Xsail, or any of the components in ONZETRA Xsail

What should I tell my healthcare provider before taking ONZETRA Xsail?

Before you take ONZETRA Xsail, tell your doctor about all your medical conditions and all the medicines you take, including prescription medicines, especially antidepressants, and all over-the-counter medicines, vitamins, and herbal supplements.

What should I avoid while taking ONZETRA Xsail?

ONZETRA Xsail can cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see the full Prescribing Information, including Patient Information and Instructions for Use for ONZETRA Xsail.
What is ONZETRA® Xsail®
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What is ONZETRA® Xsail®
ONZETRA® Xsail® is a prescription medication approved for the acute treatment of migraine, with or without aura in adults. ONZETRA Xsail is used for people who have been told by a healthcare provider that they have migraine headaches. ONZETRA Xsail is not for the prevention of migraines or for other types of headaches, including cluster headache.

© 2022 Currax Pharmaceuticals LLC.
ONZ-0035-001 06/22

All rights reserved. ONZETRA and Xsail are registered trademarks of Currax Pharmaceuticals LLC. Breath Powered is a registered trademark of OptiNose AS.

© 2022 Currax Pharmaceuticals LLC. All rights reserved. ONZETRA and Xsail are registered trademarks of Currax Pharmaceuticals LLC. Breath Powered is a registered trademark of OptiNose AS.
ONZ-0035-001 06/22

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